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Science AMA Series: I’m Dr. Domenico Accili, a Professor of Medicine at Columbia University Medical Center in New York. I’m working on a therapy for diabetes which involves re-engineering patients gut cells to produce insulin. AMA!

Hi! I'm a researcher at Columbia University Medical Center & New York Presbyterian Hospital. My team recently published a paper where we were able to take the gut cells from patient with diabetes and genetically engineer them so that they can produce insulin. These cells could help replace insulin-producing pancreatic cells destroyed by the body’s immune system in type 1 diabetes. Here’s a link to a reddit thread on my newest paper:

I’m also working on developing drugs that reverse the inactivation of beta cells in diabetes patients and reawaken them so that they can produce insulin again.

Ask me anything about diabetes treatments, drug design, personalized medicine, mouse disease models, adult stem cells, genetic engineering etc!

I will be back at 1 pm EDT to answer questions, AMA!

submitted by Dr_Domenico_Accili to science
[link] [312 comments]

IamA entrepreneur, eight years ago my wife and I sold everything and bought a 90ft tunnel oven to make cookies. Today we’re shipping 1 thousand pounds a day. AMA!

I'm a business owner and entrepreneur and I haven't worked for someone else since I was 19. My last AMA was in 2011 I'm doing this so that I can answer any questions you may have about being in business or starting your own company.

In 2006, my wife and I began selling our home-made chocolate chip cookies in Farmer's markets around LA, and today we’re baking about 1,000 pounds a day.

We named our cookies “The Best Chocolate Chip Cookies In The World” not as hype, but because we think that’s what they are. What makes them unique is that so far as we know, they're the only no-compromise chocolate chips ever produced on earth.

Here's a video we shot 10 days ago:

Our motivation has little to do with anything practical.

We procure the best ingredients attainable, not the best you can find in a grocery store, but the best you can find in the WORLD! Like imported, semi-sweet, Belgian chocolate and pure, imported, Madagascar vanilla. We blend fresh, hand-cracked eggs with the best American and imported French butter to obtain a perfect balance of flavor and smoothness and then we add unrefined cane sugar, bake them to perfection and package them for everyone to scarf-down at will!

Our cookies are pretty much the home-baked chocolate chips most people’s taste buds crave! AMA!

My Proof: Enter link here

EDIT #1: our bus: For 18 months we lived in our bus, in the parking lot of our bakery, while we learned how to bake our cookies! It took hundreds of 70 lb. batches, and thousands of pounds of scrapped cookies,

EDIT#2: I just posted a REDDIT SPECIAL on our website: Go to the "all products" section on the menu bar: SCROLL DOWN TO THE REDDIT SPECIAL. Use this special code at checkout: GOLD it includes shipping AND the code will save you 20% We'll bake on the weekend and ship USPS on Monday! Enjoy!

submitted by begreen123 to IAmA
[link] [404 comments]

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