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Science AMA Series: I’m Dr. Domenico Accili, a Professor of Medicine at Columbia University Medical Center in New York. I’m working on a therapy for diabetes which involves re-engineering patients gut cells to produce insulin. AMA!

Hi! I recently published a paper where we were able to take the gut cells from patient with diabetes and genetically engineer them so that they can produce insulin. These cells could help replace insulin-producing pancreatic cells destroyed by the body’s immune system in type 1 diabetes. Here’s a link to a reddit thread on my newest paper:

I’m also working on developing drugs that reverse the inactivation of beta cells in diabetes patients and reawaken them so that they can produce insulin again.

Ask me anything about diabetes treatments, drug design, personalized medicine, mouse disease models, adult stem cells, genetic engineering etc!

I wil be back at 1 pm EDT to answer questions, AMA!

submitted by Dr_Domenico_Accili to science
[link] [130 comments]

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